פרסומים
- Inter-tissue co-expression networks of human metabolic transcriptomes, Sussman, E. Z., Mor, D., Nataliya, L., Hochberg, I. & Somekh, J., Jun 2026, In: Heliyon. 12, 10, e44993.
- Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health, Yi, F., Yuan, J., Han, F., Somekh, J., Peleg, M., Wu, F., Jia, Z., Zhu, Y. C. & Huang, Z., 1 Apr 2025, In: Brain. 148, 4, p. 1389-1404 16 p.
- Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank, Yi, F., Yuan, J., Somekh, J., Peleg, M., Zhu, Y. C., Jia, Z., Wu, F. & Huang, Z., 14 Mar 2025, In: Science Advances. 11, 11, eadr3757.
- A computational framework for detecting inter-tissue gene-expression coordination changes with aging, Briller, S., Ben David, G., Amir, Y., Atzmon, G. & Somekh, J., Mar 2025, In: Scientific Reports. 15, 1, 11014.
- Machine learning on longitudinal multi-modal data enables the understanding and prognosis of Alzheimer's disease progression, for the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Study of Aging, 19 Jul 2024, In: iScience. 27, 7, 110263.
- Identifying underlying patterns in Alzheimer's disease trajectory: a deep learning approach and Mendelian randomization analysis, Oct 2023, In: eClinicalMedicine. 64, 102247.
- Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles, Shalev, I., Somekh, J. & Eran, A., Oct 2022, In: Journal of Medical Genetics. 59, 10, p. 1002-1009 8 p.
- A methodology for classifying tissue-specific metabolic and inflammatory receptor functions applied to subcutaneous and visceral adipose, Yehuda, G. A. & Somekh, J., Oct 2022, In: PLOS ONE. 17, 10, e0276699.
- Predicting mechanical ventilation effects on six human tissue transcriptomes, Somekh, J., Lotan, N., Sussman, E. & Yehuda, G. A., Mar 2022, In: PLOS ONE. 17, 3, e0264919.
- Model-based pathway enrichment analysis applied to the TGF-beta regulation of autophagy in autism, Somekh, J., Jun 2021, In: Journal of Biomedical Informatics. 118, 103781.
- A methodology for predicting tissue-specific metabolic roles of receptors applied to subcutaneous adipose, Somekh, J., Dec 2020, In: Scientific Reports. 10, 1, 19535.
- Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response, Haberman, Y., Karns, R., Dexheimer, P. J., Schirmer, M., Somekh, J., Jurickova, I., Braun, T., Novak, E., Bauman, L., Collins, M. H., Mo, A., Rosen, M. J., Bonkowski, E., Gotman, N., Marquis, A., Nistel, M., Rufo, P. A., Baker, S. S., Sauer, C. G. & Markowitz, J. & 22 others, , 1 Dec 2019, In: Nature Communications. 10, 1, 38.
- Batch correction evaluation framework using a-priori gene-gene associations: Applied to the GTEx dataset, Somekh, J., Shen-Orr, S. S. & Kohane, I. S., 28 May 2019, In: BMC Bioinformatics. 20, 1, 268.
- A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease, Somekh, J., Peleg, M., Eran, A., Koren, I., Feiglin, A., Demishtein, A., Shiloh, R., Heiner, M., Kong, S. W., Elazar, Z. & Kohane, I., 1 Oct 2016, In: Journal of Biomedical Informatics. 63, p. 366-378 13 p.
- Cognition-Based Visualization of the Dynamics of Conceptual Models: The Vivid OPM Scene Player, Bolshchikov, S., Somekh, J., Mazor, S., Wengrowicz, N., Choder, M. & Dori, D., Oct 2015, In: Systems Engineering. 18, 5, p. 431-440 10 p.
- Conceptual modeling of mRNA decay provokes new hypotheses, Somekh, J., Haimovich, G., Guterman, A., Dori, D. & Choder, M., 25 Sep 2014, In: PLOS ONE. 9, 9, e107085.
- Presence-awareness: A conceptual model-based systems biology approach, Mordecai, Y., Somekh, J. & Dori, D., 2014, In: Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics. 2014-January, January, p. 996-1001 6 p., 6974043.
- Conceptual Model-Based Systems Biology: Mapping Knowledge and Discovering Gaps in the mRNA Transcription Cycle, Somekh, J., Choder, M. & Dori, D., 20 Dec 2012, In: PLOS ONE. 7, 12, e51430.
- Modeling Complex biological Systems with Object-Process Methodology, SOMEKH, J., Dori, D. & Choder, M., 2011, Proc. of the 6th International Conference on Systems Engineering.
- Model verification framework with application to molecular biology, Perelman, V., Somekh, J. & Dori, D., 2011, Theory of Modeling and Simulation: DEVS Integrative M and S Symposium 2011, TMS-DEVS 2011 - 2011 Spring Simulation Multiconference, SpringSim 2011. 1 BOOK 4 ed. p. 140-145 6 p. (Simulation Series; vol. 43, no. 1 BOOK 4).
- OPM model-driven animated simulation with computational interface to Matlab, Bolshchikov, S., Renick, A., Mazor, S., Somekh, J. & Dori, D., 2011, Proceedings of the 2011 20th IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises, WETICE 2011. p. 193-198 6 p. 5990026. (Proceedings of the 2011 20th IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises, WETICE 2011).
- OPM Simulation with Computational Interface to Matlab and Model-Driven Vivid Animation, Bolshchikov, S., Renick, A., SOMEKH, J. & Dori, D., 2011, Proc. of the 6th International Conference on Systems Engineering.
- Visualizing the Dynamics of Conceptual Behavior Models: The Vivid OPM Scene Player, Bolshchikov, S., Somekh, J., Mazor, S., Monadeev, M., Hertz, S., Choder, M. & Dori, D., 2010, Proc. 3rd International Conference on Model-Based System Engineering (MBSE 2010). Fairfax, VA, USA
- A methodology for eliciting and modeling exceptions, Peleg, M., Somekh, J. & Dori, D., Aug 2009, In: Journal of Biomedical Informatics. 42, 4, p. 736-747 12 p.
- Classifying and modeling exceptions through object process methodology, Somekh, Y., Peleg, M. & Dori, D., 2007, 2007 International Conference on Systems Engineering and Modeling, ICSEM '07. p. 60-70 11 p. 4243718. (2007 International Conference on Systems Engineering and Modeling, ICSEM '07).
תחומי מחקר
- שיטות במדעי הנתונים בתחום הרפואי
- שיטות לניקוי נתונים
- אנליזת נתונים גנומיים
- מידול וסימולציה של מערכות ביולוגיות
- שילוב שיטות מבוססות נתונים עם שיטות מבוססות מודל להבנת מחלות